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Curry Spice May Slow Prostate Tumor Growth

Order up some chicken vindaloo! New research shows that curcumin, which is found in the Indian curry spice turmeric, could be beneficial for certain prostate cancer patients.

By Allison Takeda

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TUESDAY, Feb. 14, 2012 —Good news for curry lovers: Curcumin, an active component of the Indian curry spice turmeric, may help slow tumor growth in some prostate cancer patients, according to a recent study.

Led by Karen Knudsen, PhD, a professor of cancer biology, urology, and radiation oncology at Thomas Jefferson University, researchers from the Kimmel Cancer Center in Philadelphia studied prostate cancer cells in the lab and in mice and found that the presence of curcumin alongside androgen deprivation therapy, or ADT, reduced the number of cells and inhibited cell reproduction and survival in castration-resistant tumors — that is, tumors that have stopped responding to ADT.

Typically, ADT helps treat prostate cancer by reducing the body’s levels of androgens (male hormones), which help stimulate tumor growth. Lowering androgen levels can make the cancer cells shrink or develop more slowly — but only to a point. Many tumors eventually become immune to ADT and resume growth, leaving patients with few options. That’s where the curcumin comes in.

For the study, published in the journalCancer Research, Knudsen and colleagues subjected cancer cells to hormone deprivation with and without curcumin. After observing the cells in a lab, they discovered that curcumin boosted the effectiveness of ADT by suppressing two nuclear receptor activators, p300 and CPB, that have been known to work against it.

Encouraged, the team decided to test their theory in mice, too. They found that those who were treated with curcumin experienced a significant reduction in tumor growth and mass compared with those in the control group.

“This study sets the stage for further development of curcumin as a novel agent to target androgen receptor signaling,” said Dr. Knudsen.






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Date: 06.12.2018, 14:31 / Views: 53451